Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts

BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is a malignancy that is challenging to treat. Fibroblasts in ICC tissues have been identified as cancer-associated fibroblasts (CAFs) that promote the malignant behaviour of ICC cells. An antifibrotic drug nintedanib has been reported to suppress act...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Yamanaka, Takahiro, Harimoto, Norifumi, Yokobori, Takehiko, Muranushi, Ryo, Hoshino, Kouki, Hagiwara, Kei, Gantumur, Dolgormaa, Handa, Tadashi, Ishii, Norihiro, Tsukagoshi, Mariko, Igarashi, Takamichi, Tanaka, Hiroshi, Watanabe, Akira, Kubo, Norio, Araki, Kenichiro, Shirabe, Ken
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7109053/
https://ncbi.nlm.nih.gov/pubmed/32015511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0744-7
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