Direct interaction of metastasis-inducing S100P protein with tubulin causes enhanced cell migration without changes in cell adhesion

Overexpression of S100P promotes breast cancer metastasis in animals and elevated levels in primary breast cancers are associated with poor patient outcomes. S100P can differentially interact with nonmuscle myosin (NM) isoforms (IIA > IIC > IIB) leading to the redistribution of actomyosin fila...

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Udgivet i:Biochem J
Main Authors: Du, Min, Wang, Guozheng, Barsukov, Igor L., Gross, Stephane R., Smith, Richard, Rudland, Philip S.
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press Ltd. 2020
Fag:
Cancer
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108782/
https://ncbi.nlm.nih.gov/pubmed/32065231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20190644
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