Global expression and CpG methylation analysis of primary endothelial cells before and after TNFa stimulation reveals gene modules enriched in inflammatory and infectious diseases and associated DMRs

Endothelial cells are a primary site of leukocyte recruitment during inflammation. An increase in tumor necrosis factor-alpha (TNFa) levels as a result of infection or some autoimmune diseases can trigger this process. Several autoimmune diseases are now treated with TNFa inhibitors. However, genomi...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Rhead, Brooke, Shao, Xiaorong, Quach, Hong, Ghai, Poonam, Barcellos, Lisa F., Bowcock, Anne M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2020
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108734/
https://ncbi.nlm.nih.gov/pubmed/32231389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0230884
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