Nucleocapsid protein of SARS-CoV activates the expression of cyclooxygenase-2 by binding directly to regulatory elements for nuclear factor-kappa B and CCAAT/enhancer binding protein

SARS-associated coronavirus (SARS-CoV) causes inflammation and damage to the lungs resulting in severe acute respiratory syndrome. To evaluate the molecular mechanisms behind this event, we investigated the roles of SARS-CoV proteins in regulation of the proinflammatory factor, cyclooxygenase-2 (COX...

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Udgivet i:Int J Biochem Cell Biol
Main Authors: Yan, Xiaohong, Hao, Qian, Mu, Yongxin, Timani, Khalid Amine, Ye, Linbai, Zhu, Ying, Wu, Jianguo
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Ltd. 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108415/
https://ncbi.nlm.nih.gov/pubmed/16546436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2006.02.003
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