Exosomal KRAS mutation promotes the formation of tumor-associated neutrophil extracellular traps and causes deterioration of colorectal cancer by inducing IL-8 expression

BACKGROUND: Colorectal cancer (CRC) remains one of the leading causes of cancer-related death. The current study aimed to elucidate the mechanism by which exosomes carrying KRAS mutant contribute to neutrophil recruitment as well as the formation of the neutrophil extracellular trap (NET) in CRC. ME...

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Dettagli Bibliografici
Pubblicato in:Cell Commun Signal
Autori principali: Shang, Anquan, Gu, Chenzheng, Zhou, Chen, Yang, Yibao, Chen, Chen, Zeng, Bingjie, Wu, Junlu, Lu, Wenying, Wang, Weiwei, Sun, Zujun, Li, Dong
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7106821/
https://ncbi.nlm.nih.gov/pubmed/32228650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-0517-1
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