Exosomal KRAS mutation promotes the formation of tumor-associated neutrophil extracellular traps and causes deterioration of colorectal cancer by inducing IL-8 expression

BACKGROUND: Colorectal cancer (CRC) remains one of the leading causes of cancer-related death. The current study aimed to elucidate the mechanism by which exosomes carrying KRAS mutant contribute to neutrophil recruitment as well as the formation of the neutrophil extracellular trap (NET) in CRC. ME...

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Veröffentlicht in:Cell Commun Signal
Hauptverfasser: Shang, Anquan, Gu, Chenzheng, Zhou, Chen, Yang, Yibao, Chen, Chen, Zeng, Bingjie, Wu, Junlu, Lu, Wenying, Wang, Weiwei, Sun, Zujun, Li, Dong
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7106821/
https://ncbi.nlm.nih.gov/pubmed/32228650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-0517-1
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