Icariin Ameliorates Diabetic Cardiomyopathy Through Apelin/Sirt3 Signalling to Improve Mitochondrial Dysfunction

Myocardial contractile dysfunction in diabetic cardiomyocytes is a significant promoter of heart failure. Herein, we investigated the effect of icariin, a flavonoid monomer isolated from Epimedium, on diabetic cardiomyopathy (DCM) and explored the mechanisms underlying its unique pharmacological car...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Ni, Tingjuan, Lin, Na, Huang, Xingxiao, Lu, Wenqiang, Sun, Zhenzhu, Zhang, Jie, Lin, Hui, Chi, Jufang, Guo, Hangyuan
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7106769/
https://ncbi.nlm.nih.gov/pubmed/32265695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00256
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