The depletion of ubiquilin in Drosophila melanogaster disturbs neurochemical regulation to drive activity and behavioral deficits

Drosophila melanogaster is a useful and highly tractable model organism for understanding the molecular mechanisms of human diseases. We previously characterized a new dUbqn knockdown model that induces learning-memory and locomotive deficits mediated by impaired proteostasis. Although proteinopathi...

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Udgivet i:Sci Rep
Main Authors: Jantrapirom, Salinee, Enomoto, Yosuke, Karinchai, Jirarat, Yamaguchi, Mizuki, Yoshida, Hideki, Fukusaki, Eiichiro, Shimma, Shuichi, Yamaguchi, Masamitsu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105486/
https://ncbi.nlm.nih.gov/pubmed/32231214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62520-y
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