Mononuclear diploid cardiomyocytes support neonatal mouse heart regeneration in response to paracrine IGF2 signaling

Injury to the newborn mouse heart is efficiently regenerated, but this capacity is lost by one week after birth. We found that IGF2, an important mitogen in heart development, is required for neonatal heart regeneration. IGF2 originates from the endocardium/endothelium and is transduced in cardiomyo...

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Vydáno v:eLife
Hlavní autoři: Shen, Hua, Gan, Peiheng, Wang, Kristy, Darehzereshki, Ali, Wang, Kai, Kumar, S Ram, Lien, Ching-Ling, Patterson, Michaela, Tao, Ge, Sucov, Henry M
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105374/
https://ncbi.nlm.nih.gov/pubmed/32167474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53071
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