Deficiency in the anti-apoptotic protein DJ-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p53

Parkinson disease autosomal recessive, early onset 7 (PARK7 or DJ-1) is involved in multiple physiological processes and exerts anti-apoptotic effects on multiple cell types. Increased intestinal epithelial cell (IEC) apoptosis and excessive activation of the p53 signaling pathway is a hallmark of i...

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Vydáno v:J Biol Chem
Hlavní autoři: Zhang, Jie, Xu, Min, Zhou, Weihua, Li, Dejian, Zhang, Hong, Chen, Yi, Ning, Longgui, Zhang, Yuwei, Li, Sha, Yu, Mengli, Chen, Yishu, Zeng, Hang, Cen, Li, Zhou, Tianyu, Zhou, Xinxin, Lu, Chao, Yu, Chaohui, Li, Youming, Sun, Jing, Kong, Xiaoni, Shen, Zhe
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105307/
https://ncbi.nlm.nih.gov/pubmed/32075910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010143
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