Single cell force profiling of human myofibroblasts reveals a biophysical spectrum of cell states

Mechanical force is a fundamental regulator of cell phenotype. Myofibroblasts are central mediators of fibrosis, a major unmet clinical need characterised by the deposition of excessive matrix proteins. Traction forces of myofibroblasts play a key role in remodelling the matrix and modulate the acti...

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Detalles Bibliográficos
Publicado en:Biol Open
Main Authors: Layton, Thomas B., Williams, Lynn, Colin-York, Huw, McCann, Fiona E., Cabrita, Marisa, Feldmann, Marc, Brown, Cameron, Xie, Weilin, Fritzsche, Marco, Furniss, Dominic, Nanchahal, Jagdeep
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists Ltd 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104857/
https://ncbi.nlm.nih.gov/pubmed/32139395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.049809
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