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Structural basis for RNA polymerase III transcription repression by Maf1
Maf1 is a conserved inhibitor of RNA polymerase III (Pol III) that influences phenotypes from metabolic efficiency to lifespan. Here, we present a 3.3 Å cryo-EM structure of yeast Maf1 bound to Pol III, establishing that Maf1 sequesters Pol III elements involved in transcription initiation and binds...
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| Publicat a: | Nat Struct Mol Biol |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7104376/ https://ncbi.nlm.nih.gov/pubmed/32066962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0383-y |
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