Lysosomal degradation products induce Coxiella burnetii virulence

Coxiella burnetii is an intracellular pathogen that replicates in a lysosome-like vacuole through activation of a Dot/Icm-type IVB secretion system and subsequent translocation of effectors that remodel the host cell. Here a genome-wide small interfering RNA screen and reporter assay were used to id...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Newton, Patrice, Thomas, David R., Reed, Shawna C. O., Lau, Nicole, Xu, Bangyan, Ong, Sze Ying, Pasricha, Shivani, Madhamshettiwar, Piyush B., Edgington-Mitchell, Laura E., Simpson, Kaylene J., Roy, Craig R., Newton, Hayley J.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2020
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104363/
https://ncbi.nlm.nih.gov/pubmed/32152125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921344117
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