Proteolytic processing of polyproteins 1a and 1ab between non-structural proteins 10 and 11/12 of Coronavirus infectious bronchitis virus is dispensable for viral replication in cultured cells

Coronavirus 3C-like proteinase (3CLpro) plays important roles in viral life cycle through extensive processing of the polyproteins 1a and 1ab into 12 mature, non-structural proteins (nsp5–nsp16). Structural and biochemical studies have revealed that all confirmed 3CLpro cleavage sites have a conserv...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Fang, Shou Guo, Shen, Hongyuan, Wang, Jibin, Tay, Felicia P.L., Liu, Ding Xiang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2008
Assuntos:
Rapid Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7103401/
https://ncbi.nlm.nih.gov/pubmed/18678384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.06.038
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