Heterologous viral RNA export elements improve expression of severe acute respiratory syndrome (SARS) coronavirus spike protein and protective efficacy of DNA vaccines against SARS

The SARS-CoV spike glycoprotein (S) is the main target of the protective immune response in humans and animal models of SARS. Here, we demonstrated that efficient expression of S from the wild-type spike gene in cultured cells required the use of improved plasmid vectors containing donor and accepto...

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Publicado no:Virology
Main Authors: Callendret, Benoît, Lorin, Valérie, Charneau, Pierre, Marianneau, Philippe, Contamin, Hugues, Betton, Jean-Michel, van der Werf, Sylvie, Escriou, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7103356/
https://ncbi.nlm.nih.gov/pubmed/17331558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2007.01.012
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