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Cytosine deamination and selection of CpG suppressed clones are the two major independent biological forces that shape codon usage bias in coronaviruses

Using the complete genome sequences of 19 coronavirus genomes, we analyzed the codon usage bias, dinucleotide relative abundance and cytosine deamination in coronavirus genomes. Of the eight codons that contain CpG, six were markedly suppressed. The mean NNU/NNC ratio of the six amino acids using ei...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Woo, Patrick C.Y., Wong, Beatrice H.L., Huang, Yi, Lau, Susanna K.P., Yuen, Kwok-Yung
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7103290/
https://ncbi.nlm.nih.gov/pubmed/17881030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2007.08.010
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