Losartan attenuates chronic cigarette smoke exposure-induced pulmonary arterial hypertension in rats: Possible involvement of angiotensin-converting enzyme-2

Chronic cigarette smoking induces pulmonary arterial hypertension (PAH) by largely unknown mechanisms. Renin–angiotensin system (RAS) is known to function in the development of PAH. Losartan, a specific angiotensin II receptor antagonist, is a well-known antihypertensive drug with a potential role i...

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Detalhes bibliográficos
Publicado no:Toxicol Appl Pharmacol
Main Authors: Han, Su-Xia, He, Guang-Ming, Wang, Tao, Chen, Lei, Ning, Yun-Ye, Luo, Feng, An, Jin, Yang, Ting, Dong, Jia-Jia, Liao, Zeng-lin, Xu, Dan, Wen, Fu-Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7103128/
https://ncbi.nlm.nih.gov/pubmed/20178811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2010.02.009
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