Differential regulation of microRNA-15a by radiation affects angiogenesis and tumor growth via modulation of acid sphingomyelinase

Activation of acid sphingomyelinase (SMPD1) and the generation of ceramide is a critical regulator of apoptosis in response to cellular stress including radiation. Endothelial SMPD1 has been shown to regulate tumor responses to radiation therapy. We show here that the SMPD1 gene is regulated by a mi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Rana, Shushan, Espinosa-Diez, Cristina, Ruhl, Rebecca, Chatterjee, Namita, Hudson, Clayton, Fraile-Bethencourt, Eugenia, Agarwal, Anupriya, Khou, Sokchea, Thomas, Charles R., Anand, Sudarshan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7101391/
https://ncbi.nlm.nih.gov/pubmed/32221387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62621-8
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