No evidence for hypogammaglobulinemia in patients with paroxysmal nocturnal hemoglobinuria (PNH) chronically treated with ravulizumab

INTRODUCTION: Ravulizumab (ALXN1210) is a long-lasting recycling IgG monoclonal antibody with an increased affinity for the neonatal Fc receptor (FcRn). The FcRn is essential for regulating IgG homeostasis. Saturation of the FcRn pathway is seen under high IgG doses as they compete with endogenous I...

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Udgivet i:PLoS One
Main Authors: Alashkar, Ferras, Rottinghaus, Scott, Vance, Colin, Herich-Terhürne, Dörte, Dührsen, Ulrich, Assert, Roland, Röth, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7101163/
https://ncbi.nlm.nih.gov/pubmed/32218584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0230869
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