No evidence for hypogammaglobulinemia in patients with paroxysmal nocturnal hemoglobinuria (PNH) chronically treated with ravulizumab

INTRODUCTION: Ravulizumab (ALXN1210) is a long-lasting recycling IgG monoclonal antibody with an increased affinity for the neonatal Fc receptor (FcRn). The FcRn is essential for regulating IgG homeostasis. Saturation of the FcRn pathway is seen under high IgG doses as they compete with endogenous I...

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Bibliographic Details
Published in:PLoS One
Main Authors: Alashkar, Ferras, Rottinghaus, Scott, Vance, Colin, Herich-Terhürne, Dörte, Dührsen, Ulrich, Assert, Roland, Röth, Alexander
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7101163/
https://ncbi.nlm.nih.gov/pubmed/32218584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0230869
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