Targeting aminopeptidase N, a newly identified receptor for F4ac fimbriae, enhances the intestinal mucosal immune response

Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrhea in human and animal. In piglets, ETEC having F4 fimbriae (F4(+) ETEC) induce severe diarrhea, dependent on the presence of receptors for F4 (F4R). In this study, porcine aminopeptidase N (pAPN) was identified as an F4R by comparat...

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Détails bibliographiques
Publié dans:Mucosal Immunol
Auteurs principaux: Melkebeek, V, Rasschaert, K, Bellot, P, Tilleman, K, Favoreel, H, Deforce, D, De Geest, B G, Goddeeris, B M, Cox, E
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group US 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7100037/
https://ncbi.nlm.nih.gov/pubmed/22669578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2012.37
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