Dysregulated FXR-FGF19 signaling and choline metabolism are associated with gut dysbiosis and hyperplasia in a novel pig model of pediatric NASH

To investigate the role of bile acids (BAs) in the pathogenesis of diet-induced nonalcoholic steatohepatitis (NASH), we fed a “Western-style diet” [high fructose, high fat (HFF)] enriched with fructose, cholesterol, and saturated fat for 10 wk to juvenile Iberian pigs. We also supplemented probiotic...

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Publicado no:Am J Physiol Gastrointest Liver Physiol
Principais autores: Hernandez, Gabriella V., Smith, Victoria A., Melnyk, Megan, Burd, Matthew A., Sprayberry, Kimberly A., Edwards, Mark S., Peterson, Daniel G., Bennet, Darin C., Fanter, Rob K., Columbus, Daniel A., Steibel, Juan P., Glanz, Hunter, Immoos, Chad, Rice, Margaret S., Santiago-Rodriguez, Tasha M., Blank, Jason, VanderKelen, Jennifer J., Kitts, Christopher L., Piccolo, Brian D., La Frano, Michael R., Burrin, Douglas G., Maj, Magdalena, Manjarin, Rodrigo
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7099491/
https://ncbi.nlm.nih.gov/pubmed/32003601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00344.2019
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