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Neurosteroids as Selective Inhibitors of Glycine Receptor Activity: Structure-Activity Relationship Study on Endogenous Androstanes and Androstenes
The ability of androstane and androstene neurosteroids with modifications at C-17, C-5, and C-3 (compounds 1-9) to influence the functional activity of inhibitory glycine and γ-aminobutyric acid (GABA) receptors was estimated. The glycine- and GABA-induced chloride current (I(Gly) and I(GABA)) were...
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| Published in: | Front Mol Neurosci |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Frontiers Media S.A.
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7098970/ https://ncbi.nlm.nih.gov/pubmed/32265652 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.00044 |
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