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A phase 1/1b study of PUR1900, an inhaled formulation of itraconazole, in healthy volunteers and asthmatics to study safety, tolerability and pharmacokinetics

AIMS: Oral itraconazole has variable pharmacokinetics and risks of adverse events associated with high plasma exposure. An inhalation formulation of itraconazole (PUR1900) is being developed to treat allergic bronchopulmonary aspergillosis, an allergic inflammatory disease occurring in asthmatics an...

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Bibliografski detalji
Izdano u:Br J Clin Pharmacol
Glavni autori: Hava, David L., Tan, Lisa, Johnson, Patrick, Curran, Aidan K., Perry, Jason, Kramer, Steve, Kane, Katie, Bedwell, Pauline, Layton, Gary, Swann, Clarie, Henderson, Dennis, Khan, Naimat, Connor, Lucy, McKenzie, Litza, Singh, Dave, Roach, James
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098863/
https://ncbi.nlm.nih.gov/pubmed/31696544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14166
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