Neutrophil dysregulation is pathogenic in idiopathic inflammatory myopathies

Idiopathic inflammatory myopathies (IIM) are characterized by muscle inflammation and weakness, myositis-specific autoantibodies (MSAs), and extramuscular organ damage. The role of neutrophil dysregulation and neutrophil extracellular traps (NETs) in IIM is unclear. We assessed whether pathogenic ne...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Seto, Nickie, Torres-Ruiz, Jose Jiram, Carmona-Rivera, Carmelo, Pinal-Fernandez, Iago, Pak, Katherine, Purmalek, Monica M., Hosono, Yuji, Fernandes-Cerqueira, Catia, Gowda, Prateek, Arnett, Nathan, Gorbach, Alexander, Benveniste, Olivier, Gómez-Martín, Diana, Selva-O’Callaghan, Albert, Milisenda, José C., Grau-Junyent, Josep M., Christopher-Stine, Lisa, Miller, Frederick W., Lundberg, Ingrid E., Kahlenberg, J. Michelle, Schiffenbauer, Adam I., Mammen, Andrew, Rider, Lisa G., Kaplan, Mariana J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098779/
https://ncbi.nlm.nih.gov/pubmed/31945019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.134189
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