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Mechanism-Driven Read-Across of Chemical Hepatotoxicants Based on Chemical Structures and Biological Data
Hepatotoxicity is a leading cause of attrition in the drug development process. Traditional preclinical and clinical studies to evaluate hepatotoxicity liabilities are expensive and time consuming. With the advent of critical advancements in high-throughput screening, there has been a rapid accumula...
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| Vydáno v: | Toxicol Sci |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7098374/ https://ncbi.nlm.nih.gov/pubmed/32073637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfaa005 |
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