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Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer’s disease (AD) risk

Although the biochemical and pathological hallmarks of Alzheimer’s disease (AD), such as axonal transport defects, synaptic loss, and selective neuronal death, are well characterized, the underlying mechanisms that cause AD are largely unknown, thereby making it difficult to design effective therape...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Raman, Sreedevi, Brookhouser, Nicholas, Brafman, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098264/
https://ncbi.nlm.nih.gov/pubmed/32032733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.104788
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