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Why must T cells be cross-reactive?
Clonal selection theory proposed that individual T cells are specific for a single peptide–MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast array of potential foreign peptide–MHC complexes, and a comprehensive system requires each T cell to recognize numerous...
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| Udgivet i: | Nat Rev Immunol |
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| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7097784/ https://ncbi.nlm.nih.gov/pubmed/22918468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nri3279 |
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