CDK1 dependent phosphorylation of hTERT contributes to cancer progression

The telomerase reverse transcriptase is upregulated in the majority of human cancers and contributes directly to cell transformation. Here we report that hTERT is phosphorylated at threonine 249 during mitosis by the serine/threonine kinase CDK1. Clinicopathological analyses reveal that phosphorylat...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Yasukawa, Mami, Ando, Yoshinari, Yamashita, Taro, Matsuda, Yoko, Shoji, Shisako, Morioka, Masaki Suimye, Kawaji, Hideya, Shiozawa, Kumiko, Machitani, Mitsuhiro, Abe, Takaya, Yamada, Shinji, Kaneko, Mika K., Kato, Yukinari, Furuta, Yasuhide, Kondo, Tadashi, Shirouzu, Mikako, Hayashizaki, Yoshihide, Kaneko, Shuichi, Masutomi, Kenkichi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7096428/
https://ncbi.nlm.nih.gov/pubmed/32214089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15289-7
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