Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly

Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using in-cell NMR spectroscopy, we d...

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發表在:Nat Commun
Main Authors: Wang, Chuchu, Tu, Jia, Zhang, Shengnan, Cai, Bin, Liu, Zhenying, Hou, Shouqiao, Zhong, Qinglu, Hu, Xiao, Liu, Wenbin, Li, Guohui, Liu, Zhijun, He, Lin, Diao, Jiajie, Zhu, Zheng-Jiang, Li, Dan, Liu, Cong
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7093461/
https://ncbi.nlm.nih.gov/pubmed/32210233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15270-4
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