Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia

Maternal physiological (MPH) or supraphysiological hypercholesterolaemia (MSPH) occurs during pregnancy. Cholesterol trafficking from maternal to foetal circulation requires the uptake of maternal LDL and HDL by syncytiotrophoblast and cholesterol efflux from this multinucleated tissue to ApoA-I and...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Fuenzalida, Bárbara, Cantin, Claudette, Kallol, Sampada, Carvajal, Lorena, Pastén, Valentina, Contreras-Duarte, Susana, Albrecht, Christiane, Gutierrez, Jaime, Leiva, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7093446/
https://ncbi.nlm.nih.gov/pubmed/32210256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61629-4
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