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The cardiac work-loop technique: An in vitro model for identifying and profiling drug-induced changes in inotropy using rat papillary muscles

The cardiac work-loop technique closely mimics the intrinsic in vivo movement and characteristics of cardiac muscle function. In this study, six known inotropes were profiled using the work-loop technique to evaluate the potential of this method to predict inotropy. Papillary muscles from male Sprag...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Fletcher, Sophie, Maddock, Helen, James, Rob S., Wallis, Rob, Gharanei, Mayel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7093439/
https://ncbi.nlm.nih.gov/pubmed/32210283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58935-2
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