Absence of MyD88 from skeletal muscle protects female mice from inactivity-induced adiposity and insulin resistance

OBJECTIVE: Inactivity and inflammation are linked to obesity and insulin resistance. We hypothesized MyD88 (mediates inflammation) KO from muscle (MusMyD88(−/−)) would prevent, whereas miR146a(−/−) (MyD88 inhibitor) would exacerbate, inactivity-induced metabolic disturbances. METHODS: Cre-control, M...

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Bibliographic Details
Published in:Obesity (Silver Spring)
Main Authors: Mahmassani, Ziad S, Reidy, Paul T, McKenzie, Alec I, Petrocelli, Jonathan J, Matthews, O’Connor, de Hart, Naomi M, Ferrara, Patrick J, O’Connell, Ryan, Funai, Katsuhiko, Drummond, Micah J
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7093260/
https://ncbi.nlm.nih.gov/pubmed/32108446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/oby.22759
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