Genetic compensation in a stable slc25a46 mutant zebrafish: A case for using F0 CRISPR mutagenesis to study phenotypes caused by inherited disease

A phenomenon of genetic compensation is commonly observed when an organism with a disease-bearing mutation shows incomplete penetrance of the disease phenotype. Such incomplete phenotypic penetrance, or genetic compensation, is more commonly found in stable knockout models, rather than transient kno...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Buglo, Elena, Sarmiento, Evan, Martuscelli, Nicole Belliard, Sant, David W., Danzi, Matt C., Abrams, Alexander J., Dallman, Julia E., Züchner, Stephan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7092968/
https://ncbi.nlm.nih.gov/pubmed/32208444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0230566
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