Design of recombinant protein-based SARS-CoV entry inhibitors targeting the heptad-repeat regions of the spike protein S2 domain

Entry of SARS-CoV into a target cell is initiated by binding of the S1 domain of spike protein to a receptor, followed by conformational changes of the spike protein S2 domain, resulting in the formation of a six-helix bundle by the heptad-repeat (HR1 and HR2) regions. Our previous studies have demo...

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Vydáno v:Biochem Biophys Res Commun
Hlavní autoři: Ni, Ling, Zhu, Jieqing, Zhang, Junjie, Yan, Meng, Gao, George F., Tien, Po
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Inc. 2005
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7092889/
https://ncbi.nlm.nih.gov/pubmed/15781229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2005.02.117
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