Disruption or reduced expression of the orotidine-5′-decarboxylase gene pyrG increases citric acid production: a new discovery during recyclable genome editing in Aspergillus niger

BACKGROUND: Aspergillus niger is a filamentous fungus used for the majority of global citric acid production. Recent developments in genome editing now enable biotechnologists to engineer and optimize A. niger. Currently, however, genetic-leads for maximizing citric acid titers in industrial A. nige...

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Bibliographische Detailangaben
Veröffentlicht in:Microb Cell Fact
Hauptverfasser: Zhang, Lihui, Zheng, Xiaomei, Cairns, Timothy C., Zhang, Zhidan, Wang, Depei, Zheng, Ping, Sun, Jibin
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7092557/
https://ncbi.nlm.nih.gov/pubmed/32209089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-020-01334-z
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