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Lack of adverse effects during a target animal safety trial of extended-release buprenorphine in Fischer 344 rats

Extended-release buprenorphine is an effective analgesic in laboratory animals, and its safety has been established in mice but not in rats. The authors used a target animal safety trial to evaluate the safety of extended-release buprenorphine in rats. Fischer 344 rats received post-surgical subcuta...

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Dettagli Bibliografici
Pubblicato in:Lab Anim (NY)
Autori principali: Cowan, Alan, Sarabia-Estrada, Rachel, Wilkerson, Gina, McKnight, Patrick, Guarnieri, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group US 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7092016/
https://ncbi.nlm.nih.gov/pubmed/26684956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/laban.745
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