Estrogen Receptor-α Non-Nuclear Signaling Confers Cardioprotection and Is Essential to cGMP-PDE5 Inhibition Efficacy

Using genetically engineered mice lacking estrogen receptor-α non-nuclear signaling, this study demonstrated that estrogen receptor−α non-nuclear signaling activated myocardial cyclic guanosine monophosphate-dependent protein kinase G and conferred protection against cardiac remodeling induced by pr...

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Dettagli Bibliografici
Pubblicato in:JACC Basic Transl Sci
Autori principali: Fukuma, Nobuaki, Takimoto, Eiki, Ueda, Kazutaka, Liu, Pangyen, Tajima, Miyu, Otsu, Yu, Kariya, Taro, Harada, Mutsuo, Toko, Haruhiro, Koga, Kaori, Blanton, Robert M., Karas, Richard H., Komuro, Issei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
Soggetti:
PRECLINICAL RESEARCH
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7091505/
https://ncbi.nlm.nih.gov/pubmed/32215350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2019.12.009
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