Structure-Based Screening of Plasmodium berghei Glutathione S-Transferase Identifies CB-27 as a Novel Antiplasmodial Compound

Plasmodium falciparum parasites are increasingly drug-resistant, requiring the search for novel antimalarials with distinct modes of action. Enzymes in the glutathione pathway, including glutathione S-transferase (GST), show promise as novel antimalarial targets. This study aims to better understand...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Colón-Lorenzo, Emilee E., Colón-López, Daisy D., Vega-Rodríguez, Joel, Dupin, Alice, Fidock, David A., Baerga-Ortiz, Abel, Ortiz, José G., Bosch, Jürgen, Serrano, Adelfa E.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7090221/
https://ncbi.nlm.nih.gov/pubmed/32256353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00246
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