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Engineering, delivery, and biological validation of artificial microRNA clusters for gene therapy applications
The cellular machinery regulating microRNA biogenesis and maturation relies on a small number of simple steps and minimal biological requirements, and is broadly conserved in all eukaryotic cells. The same holds true in disease. This allows for a significant degree of freedom in the engineering of t...
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| Publicado no: | Nat Protoc |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7089775/ https://ncbi.nlm.nih.gov/pubmed/31748752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41596-019-0241-8 |
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