APTO-253 Is a New Addition to the Repertoire of Drugs that Can Exploit DNA BRCA1/2 Deficiency

APTO-253 is a small molecule with antiproliferative activity against cell lines derived from a wide range of human malignancies. We sought to determine the mechanisms of action and basis for resistance to APTO-253 so as to identify synthetic lethal interactions that can guide combination studies. Th...

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Udgivet i:Mol Cancer Ther
Main Authors: Tsai, Cheng-Yu, Sun, Si, Zhang, Hongying, Local, Andrea, Su, Yongxuan, Gross, Larry A., Rice, William G., Howell, Stephen B.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7087411/
https://ncbi.nlm.nih.gov/pubmed/29626126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0834
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