Variability in HIV-1 Integrase Gene and 3′-Polypurine Tract Sequences in Cameroon Clinical Isolates, and Implications for Integrase Inhibitors Efficacy

Integrase strand-transfer inhibitors (INSTIs) are now included in preferred first-line antiretroviral therapy (ART) for HIV-infected adults. Studies of Western clade-B HIV-1 show increased resistance to INSTIs following mutations in integrase and nef 3′polypurine tract (3′-PPT). With anticipated shi...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Acharya, Arpan, Tagny, Claude T., Mbanya, Dora, Fonsah, Julius Y., Nchindap, Emilienne, Kenmogne, Léopoldine, Jihyun, Ma, Njamnshi, Alfred K., Kanmogne, Georgette D.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084836/
https://ncbi.nlm.nih.gov/pubmed/32106437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21051553
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