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Exploring Diverse-Ring Analogues on Combretastatin A4 (CA-4) Olefin as Microtubule-Targeting Agents

Combretastatin-4 (CA-4) as a tubulin polymerization inhibitor draws extensive attentions. However, due to its weak stability of cis-olefin and poor metabolic stability, structure modifications on cis-configuration are being performed. In this work, we constructed a series of novel CA-4 analogues wit...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Song, Ming-Yu, He, Qiu-Rui, Wang, Yi-Lin, Wang, Hao-Ran, Jiang, Tian-Cheng, Tang, Jiang-Jiang, Gao, Jin-Ming
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084768/
https://ncbi.nlm.nih.gov/pubmed/32155790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21051817
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