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Differential Inhibitory Actions of Multitargeted Tyrosine Kinase Inhibitors on Different Ionic Current Types in Cardiomyocytes

Lapatinib (LAP) and sorafenib (SOR) are multitargeted tyrosine kinase inhibitors (TKIs) with antineoplastic properties. In clinical observations, LAP and SOR may contribute to QTc prolongation, but the detailed mechanism for this has been largely unexplored. In this study, we investigated whether LA...

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Bibliografische gegevens
Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Chang, Wei-Ting, Liu, Ping-Yen, Lee, Kaisen, Feng, Yin-Hsun, Wu, Sheng-Nan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084345/
https://ncbi.nlm.nih.gov/pubmed/32121388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21051672
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