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Differential Inhibitory Actions of Multitargeted Tyrosine Kinase Inhibitors on Different Ionic Current Types in Cardiomyocytes

Lapatinib (LAP) and sorafenib (SOR) are multitargeted tyrosine kinase inhibitors (TKIs) with antineoplastic properties. In clinical observations, LAP and SOR may contribute to QTc prolongation, but the detailed mechanism for this has been largely unexplored. In this study, we investigated whether LA...

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Dades bibliogràfiques
Publicat a:Int J Mol Sci
Autors principals: Chang, Wei-Ting, Liu, Ping-Yen, Lee, Kaisen, Feng, Yin-Hsun, Wu, Sheng-Nan
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084345/
https://ncbi.nlm.nih.gov/pubmed/32121388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21051672
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