Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated Streptomyces

We report the isolation and characterization of three new nybomycins (nybomycins B–D, 1–3) and six known compounds (nybomycin, 4; deoxynyboquinone, 5; α-rubromycin, 6; β-rubromycin, 7; γ-rubromycin, 8; and [2α(1E,3E),4β]-2-(1,3-pentadienyl)-4-piperidinol, 9) from the Rock Creek (McCreary County, KY)...

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Detalhes bibliográficos
Publicado no:J Nat Prod
Main Authors: Wang, Xiachang, Elshahawi, Sherif I., Ponomareva, Larissa V., Ye, Qing, Liu, Yang, Copley, Gregory C., Hower, James C., Hatcher, Bruce E., Kharel, Madan K., Van Lanen, Steven G., She, Qing-Bai, Voss, S. Randal, Thorson, Jon S., Shaaban, Khaled A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084111/
https://ncbi.nlm.nih.gov/pubmed/31833370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jnatprod.9b01015
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