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NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance

Axon pathfinding is critical for nervous system development, and it is orchestrated by molecular cues that activate receptors on the axonal growth cone. Robo family receptors bind Slit guidance cues to mediate axon repulsion. In mammals, the divergent family member Robo3 does not bind Slits, but ins...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Pak, Joseph S., DeLoughery, Zachary J., Wang, Jing, Acharya, Nischal, Park, Yeonwoo, Jaworski, Alexander, Özkan, Engin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083938/
https://ncbi.nlm.nih.gov/pubmed/32198364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15211-1
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