Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity

Tumour cell phagocytosis by antigen presenting cells (APCs) is critical to the generation of antitumour immunity. However, cancer cells can evade phagocytosis by upregulating anti-phagocytosis molecule CD47. Here, we show that CD47 blockade alone is inefficient in stimulating glioma cell phagocytosi...

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Udgivet i:Nat Commun
Main Authors: von Roemeling, Christina A., Wang, Yifan, Qie, Yaqing, Yuan, Hengfeng, Zhao, Hai, Liu, Xiujie, Yang, Zhaogang, Yang, Mingming, Deng, Weiye, Bruno, Katelyn A., Chan, Charles K., Lee, Andrew S., Rosenfeld, Stephen S., Yun, Kyuson, Johnson, Aaron J., Mitchell, Duane A., Jiang, Wen, Kim, Betty Y. S.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083893/
https://ncbi.nlm.nih.gov/pubmed/32198351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15129-8
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