Efficacy of the Benznidazole+Posaconazole combination therapy in parasitemia reduction: An experimental murine model of acute Chagas

INTRODUCTION: Benznidazole (BZL) and Nifurtimox (NFX) are the pharmacological treatment for acute phase Chagas Disease (CD); however, therapy resistance and residual mortality development remain important unresolved issues. Posaconazole (POS) has shown a trypanocidal effect in vivo and in vitro. Thu...

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Detalhes bibliográficos
Publicado no:Rev Soc Bras Med Trop
Main Authors: Echeverría, Luis Eduardo, González, Clara Isabel, Hernandez, Julio Cesar Mantilla, Díaz, Martha Lucia, Eduardo, Javier, López-Romero, Luis Alberto, Rivera, Julián David, Suárez, Edwin Uriel, Ochoa, Sergio Alejandro Gómez, Rojas, Lyda Z., Morillo, Carlos A.
Formato: Artigo
Idioma:Inglês
Publicado em: Sociedade Brasileira de Medicina Tropical - SBMT 2020
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Major Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083359/
https://ncbi.nlm.nih.gov/pubmed/32049205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/0037-8682-0477-2019
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