The Degree of t-System Remodeling Predicts Negative Force-Frequency Relationship and Prolonged Relaxation Time in Failing Human Myocardium

The normally positive cardiac force-frequency relationship (FFR) becomes flat or negative in chronic heart failure (HF). Here we explored if remodeling of the cardiomyocyte transverse tubular system (t-system) is associated with alterations in FFR and contractile kinetics in failing human myocardium...

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Pubblicato in:Front Physiol
Autori principali: Abu-Khousa, Maha, Fiegle, Dominik J., Sommer, Sophie T., Minabari, Ghazali, Milting, Hendrik, Heim, Christian, Weyand, Michael, Tomasi, Roland, Dendorfer, Andreas, Volk, Tilmann, Seidel, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Physiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083140/
https://ncbi.nlm.nih.gov/pubmed/32231589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00182
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