High cholesterol induces apoptosis and autophagy through the ROS-activated AKT/FOXO1 pathway in tendon-derived stem cells

BACKGROUND: Hypercholesterolemia increases the risk of tendon pain and tendon rupture. Tendon-derived stem cells (TDSCs) play a vital role in the development of tendinopathy. Our previous research found that high cholesterol inhibits tendon-related gene expression in TDSCs. Whether high cholesterol...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Li, Kaiqun, Deng, Ye, Deng, Ganming, Chen, Pengyu, Wang, Yutian, Wu, Hangtian, Ji, Zhiguo, Yao, Zilong, Zhang, Xianrong, Yu, Bin, Zhang, Kairui
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7082977/
https://ncbi.nlm.nih.gov/pubmed/32197645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-020-01643-5
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