Discovery and Mechanistic Study of a Novel Human STING Agonist

Stimulator of interferon genes (STING) is an integral ER membrane protein that can be activated by 2’3’-cGAMP synthesized by cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) upon binding of double-stranded DNA and activates interferon (IFN) and inflammatory cytokine response to...

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Publicado no:ACS Infect Dis
Main Authors: Zhang, Xiaohui, Liu, Bowei, Tang, Liudi, Su, Qing, Hwang, Nicky, Sehgal, Mohit, Cheng, Junjun, Ma, Julia, Zhang, Xuexiang, Tan, Yinfei, Zhou, Yan, Duan, Zhongping, DeFilippis, Victor R., Viswanathan, Usha, Kulp, John, Du, Yanming, Guo, Ju-Tao, Chang, Jinhong
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7082846/
https://ncbi.nlm.nih.gov/pubmed/31060350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.9b00010
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